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Only slight to moderate increase in olanzapine clearance has been observed.

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chlorpheniramine; dihydrocodeine; phenylephrine moderate additive effects are possible when olanzapine is combined with other drugs which cause respiratory depression and or cns depression, including opiate agonists.

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table 14 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred in 2 or more of patients treated with the combination of olanzapine doses 5 mg day and lithium or valproate and with incidence greater than lithium or valproate alone who participated in the acute phase of placebo-controlled combination trials.

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in an 18 month co-therapy study in manic or mixed episode patients stabilised with olanzapine plus a mood stabiliser lithium or valproate , long-term olanzapine co-therapy with lithium or valproate was not statistically significantly superior to lithium or valproate alone in delaying bipolar recurrence, defined according to syndromic diagnostic criteria.
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