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Penicillin or other allergyRenal impairmentHistory of GI diseaseChew tabsphenylketonuriaLabor and deliveryPregnancyCat.BNursing mothers.

Hypersensitivity reactionAnaphylactic/anaphylactoid reactionsincluding shock and fatalitieshave been reported with the use of cefiximeBefore therapy with SUPRAX is institutedcareful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporinspenicillinsor other drugsDiscontinue use if a reaction occursClostridium difficile associated diarrheaEvaluate if diarrhea occursDose Adjustment in Renal ImpairmentThe dose of SUPRAX should be adjusted in patients with renal impairment and those undergoing continuous ambulatory peritoneal dialysis and hemodialysisCoagulation EffectsCephalosporinsincluding SUPRAXmay be associated with a fall in prothrombin activityProthrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicatedPhenylketonuricsSUPRAX Chewable Tablets contain aspartamea source of phenylalanine.

The following adverse reactions have been reported following the post-approval use of cefiximeIncidence rates were less than 1 in 50less than 2

Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy.

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