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Antagonism at receptors other than dopamine and 5ht2 may explain some of the other therapeutic and side effects of olanzapine.

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Bipolar I DisorderManic or Mixed EpisodesOlanzapine as Adjunct to Lithium or ValproateIn a study of patients who were already tolerating either lithium or valproate as monotherapydiscontinuation rates due to adverse reactions were 11for the combination of oral olanzapine with lithium or valproate compared to 2for patients who remained on lithium or valproate monotherapyDiscontinuations with the combination of oral olanzapine and lithium or valproate that occurred in more than 1 patient weresomnolence3weight gain1and peripheral edema1

Keep out of reach of childrenIn case of overdoseget medical help or contact a Poison Control Center immediately.

Examples of drugs that can cause interactions with olanzapine are listed below.

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similar to other antipsychotic agents, cases of ecg changes and serious cardiac or respiratory events have been reported with olanzapine therapy, but these events are infrequent.