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The level of phenytoin should be carefully monitored in patients taking XELODA and phenytoin dose may need to be reduced [see DOSAGE AND ADMINISTRATION ]. Postmarketing reports indicate that some patients receiving XELODA and phenytoin had toxicity associated with elevated phenytoin levels. Formal drug-drug interaction studies with phenytoin have not been conducted.but the mechanism of interaction is presumed to be inhibition of the CYP2C9 isoenzyme by capecitabine and/or its metabolites.

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Capecitabine is used to treat breast.colon.order xeloda pancreatic rectal cancer. It works by slowing or stopping the growth of cancer cells.

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