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Prograf, a calcineurin-inhibitor immunosuppressant, is available for oral administration as hard gelatin capsules tacrolimus extended-release capsules containing the equivalent of 0.
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Absorption is variable and the mean oral bioavailability of tacrolimus investigated with the prograf formulation is in the range of 20 – 25 individual range in adult patients 6 – 43 .
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The main purpose of this study is to investigate whether tacrolimus, extracted from expired commercial prograf capsules 5 mg , retains purity and pharmacological activity.
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prograf is indicated for the prophylaxis of organ rejection in kidney transplant patients in combination with other immunosuppressants.