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Reactions were noted after single or multiple low, intermediate, or high doses of methotrexate in patients with neoplastic and non-neoplastic diseases.

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concomitant use with high-dose methotrexate may elevate and prolong serum levels of methotrexate and or its metabolite, possibly leading to methotrexate toxicities.

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2 methotrexate patients dropped out one due to pulmonary tuberculosis and the other because of urticaria and severe dyspepsia .

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