Pediatrics the safety and efficacy of epivir-hbv were evaluated in a double-blind clinical trial in 286 patients ranging from 2 to 17 years of age, who were randomized 2 1 to receive 52 weeks of lamivudine 3 mg kg once daily to a maximum of 100 mg once daily or placebo.
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in studies of non hiv-infected patients with chronic hepatitis b, hbv isolates with ymdd mutations were detected in some patients who received lamivudine daily for 6 months or more, and were associated with evidence of diminished treatment response; similar hbv mutants have been reported in hiv-infected patients who received lamivudine-containing antiretroviral regimens in the presence of concurrent infection with hepatitis b virus see precautions and epivir-hbv package insert .
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